Phosphine-catalyzed enantioselective synthesis of oxygen heterocycles.

ABSTRACT: Chiral phosphepine 1 catalyzes the transformation of an array of hydroxy-2-alkynoates into saturated oxygen heterocycles with good enantioselectivity. Phenols are also shown to participate in such phosphine-catalyzed cyclizations, including an asymmetric variant. This method provides a new approach to the enantioselective synthesis of tetrahydrofurans, tetrahydropyrans, and dihydrobenzopyrans.

SUBMITTER: Chung YK 

PROVIDER: S-EPMC2747790 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature