Genome-wide identification of Saccharomyces cerevisiae genes required for maximal tolerance to ethanol.

ABSTRACT: The understanding of the molecular basis of yeast resistance to ethanol may guide the design of rational strategies to increase process performance in industrial alcoholic fermentations. In this study, the yeast disruptome was screened for mutants with differential susceptibility to stress induced by high ethanol concentrations in minimal growth medium. Over 250 determinants of resistance to ethanol were identified. The most significant gene ontology terms enriched in this data set are those associated with intracellular organization, biogenesis, and transport, in particular, regarding the vacuole, the peroxisome, the endosome, and the cytoskeleton, and those associated with the transcriptional machinery. Clustering the proteins encoded by the identified determinants of ethanol resistance

SUBMITTER: Teixeira MC 

PROVIDER: S-EPMC2747848 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature