Role of transporter proteins in bile tolerance of Lactobacillus acidophilus.

ABSTRACT: Lactobacillus acidophilus NCFM derivatives containing deletion mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile. These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential accumulations of ciprofloxacin and taurocholate.

SUBMITTER: Pfeiler EA 

PROVIDER: S-EPMC2747850 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature