MosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis.

ABSTRACT: Latent tuberculosis represents a high-risk burden for one-third of the world population. Previous analysis of murine tuberculosis identified a novel transcriptional regulator encoded by Rv0348 that could control the establishment of persistent tuberculosis. Disruption of the Rv0348 gene from the genome of the virulent H37Rv strain of Mycobacterium tuberculosis revealed a global impact on the transcriptional profiles of 163 genes, including induction of the mammalian cell entry (mce1) operon and the repression of a significant number of genes involved in hypoxia and starvation responses. Nonetheless, gel shift assays did not reveal direct binding between Rv0348 and a set of regulated promoters, suggesting an indirect regulatory role. However, when expressed in Mycobacterium smegmatis, the R

SUBMITTER: Abomoelak B 

PROVIDER: S-EPMC2747884 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature