Complicated urinary tract infection is associated with uroepithelial expression of proinflammatory protein S100A8.

ABSTRACT: F344 rats chronically infected with Ureaplasma parvum develop two distinct profiles: asymptomatic urinary tract infection (UTI) and UTI complicated by struvite urolithiasis. To identify factors that affect disease outcome, we characterized the temporal host immune response during infection by histopathologic analysis and in situ localization of U. parvum. We also used differential quantitative proteomics to identify distinguishing host cellular responses associated with complicated UTI. In animals in which microbial colonization was limited to the mucosal surface, inflammation was indistinguishable from that which occurred in sham-inoculated controls, and the inflammation resolved by 72 h postinoculation (p.i.) in both groups. However, inflammation persisted in animals with microbial colon

SUBMITTER: Reyes L 

PROVIDER: S-EPMC2747944 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature