Genetic polymorphism of MCP-1-2518, IL-8-251 and susceptibility to acute pancreatitis: a pilot study in population of Suzhou, China.

ABSTRACT:

Aim

To study the relationship between MCP-1-2518A/G, IL-8-251A/T polymorphism and acute pancreatitis (AP) in the Han population of Suzhou, China.

Methods

A case-control study was conducted to compare the distribution of genotype and genetic frequency of MCP-1-2518A/G, IL-8-251A/T gene polymorphism among AP (n = 101), including mild AP (n = 78) and severe AP (n = 23) and control healthy individuals (n = 120) with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing, and analyze the relationship between the MCP-1-2518A/G, IL-8-251A/T gene polymorphism and the susceptibility to AP.

Results

Significant differences were found in the distribution of genotype of MCP-1-2518A/G between the healthy control group and mild AP group (chi

SUBMITTER: Chen WC 

PROVIDER: S-EPMC2748212 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature