A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema.

ABSTRACT:

Objective

To evaluate the efficacy and safety of 1-mg and 4-mg doses of preservative-free intravitreal triamcinolone in comparison with focal/grid photocoagulation for the treatment of diabetic macular edema (DME).

Design

Multicenter, randomized clinical trial.

Participants

Eight hundred forty study eyes of 693 subjects with DME involving the fovea and with visual acuity of 20/40 to 20/320.

Methods

Eyes were randomized to focal/grid photocoagulation (n = 330), 1 mg intravitreal triamcinolone (n = 256), or 4 mg intravitreal triamcinolone (n = 254). Retreatment was given for persistent or new edema at 4-month intervals. The primary outcome was evaluated at 2 years.

Main outcome measures

Visual acuity measured with the electronic Early Treatment Diabetic Re

SUBMITTER: Diabetic Retinopathy Clinical Research Network 

PROVIDER: S-EPMC2748264 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature