Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas.

ABSTRACT:

Objectives

Glial-derived primary brain tumours, gliomas, are among the fastest growing malignancies and present a huge clinical challenge. Research suggests an important, yet poorly understood, role of ion channels in growth control of normal and malignant cells. In this study, we sought to functionally characterize Transient Receptor Potential Canoncial (TRPC) channels in glioma cell proliferation. TRPC channels form non-selective cation channels that have been suggested to represent a Ca(2+) influx pathway impacting cellular growth.

Materials and methods

Employing a combination of molecular, biochemical and biophysical techniques, we characterized TRPC channels in glioma cells.

Results

We showed consistent expression of four channel family members (TRPC-1, -3, -5, -

SUBMITTER: Bomben VC 

PROVIDER: S-EPMC2748659 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature