Continuous antiretroviral therapy decreases bone mineral density.

ABSTRACT:

Objectives

To assess the effects of antiretroviral therapy (ART) on bone mineral density (BMD) DESIGN: Randomized comparison of continuous ART (viral suppression group; VS) with intermittent ART (drug conservation group; DC) SETTING: Outpatient clinics in the United States, Australia, and Spain.

Participants

Participants in the Strategies for Management of Antiretroviral Therapy (SMART) Body Composition substudy.

Main outcome measures

Annual hip and spine BMD by dual-energy radiographic absorptiometry (DXA) and spine BMD by quantitative computed tomography (qCT).

Methods

Comparisons were by intention-to-treat analysis, using longitudinal models for change in BMD. Risk factors for BMD loss were evaluated.

Results

The 214 participants (median 44 years, 19%

SUBMITTER: Grund B 

PROVIDER: S-EPMC2748675 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature