DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes.

ABSTRACT: The DNA-templated polymerization of synthetic building blocks provides a potential route to the laboratory evolution of sequence-defined polymers with structures and properties not necessarily limited to those of natural biopolymers. We previously reported the efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid (PNA) aldehydes. Here, we report the enzyme-free, DNA-templated polymerization of side-chain-functionalized PNA tetramer and pentamer aldehydes. We observed that polymerization of tetramer and pentamer PNA building blocks with a single lysine-based side chain at various positions in the building block could proceed efficiently and sequence specifically. In addition, DNA-templated polymerization also proceeded efficiently and in a sequence-specific ma

SUBMITTER: Kleiner RE 

PROVIDER: S-EPMC2748799 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature