Dataset Information

Risk of testicular cancer in men with abnormal semen characteristics: cohort study.

ABSTRACT:

Objective

To explore the associations between semen characteristics and subsequent risk of testicular cancer.

Design

Cohort study.

Participants

32 442 men who had a semen analysis done at the Sperm Analysis Laboratory in Copenhagen during 1963-95.

Main outcome measure

Standardised incidence ratios of testicular cancer compared with total population of Danish men.

Results

Men in couples with fertility problems were more likely to develop testicular cancer than other men (89 cases, standardised incidence ratio 1.6; 95% confidence interval 1.3 to 1.9). The risk was relatively constant with increasing time between semen analysis and cancer diagnosis. Analysis according to specific semen characteristics showed that low semen concentration (standardised incidence ratio 2.3), poor motility of the spermatozoa (2.5), and high proportion of morphologically abnormal spermatozoa (3.0) were all associated with an increased risk of testicular cancer. The only other cancer group that showed increased incidence was "peritoneum and other digestive organs" (six cases; 3.7, 1.3 to 8.0). Of these, two cases were probably and two cases were possibly extragonadal germ cell tumours.

Conclusions

The results point towards the existence of common aetiological factors for low semen quality and testicular cancer. Low semen quality may also be associated with increased incidence of extragonadal germ cell tumours.

SUBMITTER: Jacobsen R

PROVIDER: S-EPMC27489 | biostudies-literature | 2000 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Risk of testicular cancer in men with abnormal semen characteristics: cohort study.

Jacobsen R R Bostofte E E Engholm G G Hansen J J Olsen J H JH Skakkebaek N E NE Moller H H

BMJ (Clinical research ed.) 20000901 7264

<h4>Objective</h4>To explore the associations between semen characteristics and subsequent risk of testicular cancer.<h4>Design</h4>Cohort study.<h4>Participants</h4>32 442 men who had a semen analysis done at the Sperm Analysis Laboratory in Copenhagen during 1963-95.<h4>Main outcome measure</h4>Standardised incidence ratios of testicular cancer compared with total population of Danish men.<h4>Results</h4>Men in couples with fertility problems were more likely to develop testicular cancer than ...[more]

PMID: 11009515

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Project description:There has recently been an explosion of studies implicating the human microbiome in playing a critical role in many disease and wellness states. The etiology of abnormal semen analysis (SA) parameters is not identified in 30% of cases; investigations involving the semen microbiome may bridge this gap. Here, we explore the relationship between the semen microbiome and alterations of sperm parameters. We recruited men presenting for fertility evaluation or vasectomy consultation with proven biological paternity. SA and next generation sequencing was performed. Differential abundance testing using Analysis of composition of Microbiota with Bias Correction (ANCOM-BC) was performed along with canonical correlational analysis for microbial community profiling. Men with abnormal (N = 27) sperm motility showed a higher abundance of Lactobacillus iners compared to those with normal (N = 46) sperm motility (mean proportion 9.4% versus 2.6%, p = 0.046). This relationship persisted on canonical correlational analysis (r = 0.392, p = 0.011). Men with abnormal sperm concentration (N = 20) showed a higher abundance of Pseudomonas stutzeri (2.1% versus 1.0%, p = 0.024) and Pseudomonas fluorescens (0.9% versus 0.7%, p = 0.010), but a lower abundance of Pseudomonas putida (0.5% versus 0.8%, p = 0.020), compared to those with normal sperm concentration (N = 53). Major limitations are related to study design (cross-sectional, observational). Our results suggest that a small group of microorganisms may play a critical role in observed perturbations of SA parameters. Some of these microbes, most notably Lactobacillus iners, have been described extensively within other, fertility-related, contexts, whereas for others, this is the first report where they have potentially been implicated. Advances in our understanding of the semen microbiome may contribute to potentially new therapeutic avenues for correcting impairments in sperm parameters and improving male fertility.

Dataset Information

Risk of testicular cancer in men with abnormal semen characteristics: cohort study.

Objective

Design

Participants

Main outcome measure

Results

Conclusions

Publications

Risk of testicular cancer in men with abnormal semen characteristics: cohort study.

Similar Datasets

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