Progressive aphasia secondary to Alzheimer disease vs FTLD pathology.

ABSTRACT:

Background

The pathology causing progressive aphasia is typically a variant of frontotemporal lobar degeneration, especially with ubiquitin-positive inclusions (FTLD-U). Less commonly the underlying pathology is Alzheimer disease (AD).

Objective

To compare clinicopathologic and MRI features of subjects with progressive aphasia and AD pathology to subjects with aphasia and FTLD-U pathology and subjects with typical AD.

Methods

We identified 5 subjects with aphasia and AD pathology and 5 with aphasia and FTLD-U pathology with an MRI from a total of 216 aphasia subjects. Ten subjects with typical AD clinical features and AD pathology were also identified. All subjects with AD pathology underwent pathologic reanalysis with TDP-43 immunohistochemistry. Voxel-based morphome

SUBMITTER: Josephs KA 

PROVIDER: S-EPMC2749307 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature