Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae.

ABSTRACT: Neisseria gonorrhoeae has the capacity to acquire iron from its human host by removing this essential nutrient from serum transferrin. The transferrin binding proteins, TbpA and TbpB constitute the outer membrane receptor complex responsible for binding transferrin, extracting the tightly bound iron from the host-derived molecule, and transporting iron into the periplasmic space of this Gram-negative bacterium. Once iron is transported across the outer membrane, ferric binding protein A (FbpA) moves the iron across the periplasmic space and initiates the process of transport into the bacterial cytosol. The results of the studies reported here define the multiple steps in the iron transport process in which TbpA and TbpB participate. Using the SUPREX technique for assessing the thermodynami

SUBMITTER: Siburt CJ 

PROVIDER: S-EPMC2749328 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature