Detection of molecular paths associated with insulitis and type 1 diabetes in non-obese diabetic mouse.

ABSTRACT: Recent clinical evidence suggests important role of lipid and amino acid metabolism in early pre-autoimmune stages of type 1 diabetes pathogenesis. We study the molecular paths associated with the incidence of insulitis and type 1 diabetes in the Non-Obese Diabetic (NOD) mouse model using available gene expression data from the pancreatic tissue from young pre-diabetic mice. We apply a graph-theoretic approach by using a modified color coding algorithm to detect optimal molecular paths associated with specific phenotypes in an integrated biological network encompassing heterogeneous interaction data types. In agreement with our recent clinical findings, we identified a path downregulated in early insulitis involving dihydroxyacetone phosphate acyltransferase (DHAPAT), a key regulator of et

SUBMITTER: Lindfors E 

PROVIDER: S-EPMC2749452 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature