SNP discovery and haplotype analysis in the segmentally duplicated DRD5 coding region.

ABSTRACT: The dopamine receptor 5 gene (DRD5) holds much promise as a candidate locus for contributing to neuropsychiatric disorders and other diseases influenced by the dopaminergic system, as well as having potential to affect normal behavioral variation. However, detailed analyses of this gene have been complicated by its location within a segmentally duplicated chromosomal region. Microsatellites and SNPs upstream from the coding region have been used for association studies, but we find, using bioinformatics resources, that these markers all lie within a previously unrecognized second segmental duplication (SD). In order to accurately analyze the DRD5 locus for polymorphisms in the absence of contaminating pseudogene sequences, we developed a fast and reliable method for sequence analysis and g

SUBMITTER: Housley DJ 

PROVIDER: S-EPMC2749463 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature