Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits.

ABSTRACT: A link has been established between prenatal nutrition and the development of metabolic and cardiovascular diseases later in life, a process referred to as developmental programming. It has been suggested that the trajectory of development is shifted by alterations in the maternal nutritional state leading to changes in developmental plasticity, in part underpinned by epigenetic changes in gene regulation. However, to date, only candidate gene approaches have been used to assess expression and molecular changes in the offspring of maternally undernourished animals. Furthermore, most work has focused on animals at an age where the programmed phenotype is already manifest and little is known about changes in gene expression in the offspring prior to development of obesity and related metabol

SUBMITTER: Morris TJ 

PROVIDER: S-EPMC2749934 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature