Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity.

ABSTRACT:

Background

One of the greatest impediments to cancer immunotherapy is the paucity of antigens that are tumor specific, sufficiently immunogenic, and shared among patients. Mucosa-restricted antigens that are expressed by tumor cells represent a novel class of vaccine targets that are characterized by immunologic privilege, which limits systemic tolerance to those antigens, and immunologic partitioning, which shields mucosae from systemic autoimmune responses. Here we defined the immunogenicity and antitumor efficacy of guanylyl cyclase C (GCC), a protein that is normally restricted to intestinal mucosa and universally expressed by metastatic colorectal cancer.

Methods

BALB/c mice (n = 197) were immunized with recombinant GCC-expressing viral vectors before (prophylactic) or

SUBMITTER: Snook AE 

PROVIDER: S-EPMC2749952 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature