ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.

ABSTRACT: Despite the importance of epidermal growth factor receptor (EGFR) in animal development and malignant transformation, surprisingly little is known about the regulation of its expression. Here, we report a novel zinc finger and G-patch domain-containing protein, ZIP. We demonstrated that ZIP acts as a transcription repressor through the recruitment of the nucleosome remodelling and deacetylase complex. Transcriptional target analysis revealed that ZIP regulates several cellular signalling pathways including EGFR pathways that are critically involved in cell proliferation, survival, and migration. We showed that ZIP inhibits cell proliferation and suppresses breast carcinogenesis, and that ZIP depletion leads to a drastic tumour growth in vivo. We found that ZIP is downregulated in breast ca

SUBMITTER: Li R 

PROVIDER: S-EPMC2750020 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature