Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring.

ABSTRACT:

Context

As we identify genes involved in psychiatric disorders, the next step will be to study how the risk associated with susceptibility genes manifests across development and in conjunction with the environment. We describe analyses aimed at characterizing the pathway of risk associated with GABRA2, a gene previously associated with adult alcohol dependence, in a community sample of children followed longitudinally from childhood through young adulthood.

Objective

To test for an association between GABRA2 and trajectories of externalizing behavior from adolescence to young adulthood and for moderation of genetic effects by parental monitoring.

Design

Data were analyzed from the Child Development Project, with yearly assessments conducted since that time. A saliva s

SUBMITTER: Dick DM 

PROVIDER: S-EPMC2750080 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature