Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

ABSTRACT:

Introduction

Germline mutations in the BRCA1 and BRCA2 genes account for a considerable fraction of familial predisposition to breast cancer. Somatic mutations in BRCA1 and BRCA2 have not been found and the involvement of these genes in sporadic tumour development therefore remains unclear.

Methods

The study group consisted of 67 primary breast tumours with and without BRCA1 or BRCA2 abnormalities. Genomic alterations were profiled by high-resolution (~7 kbp) comparative genome hybridisation (CGH) microarrays. Tumour phenotypes were analysed by immunohistochemistry on tissue microarrays using selected biomarkers (ER, PR, HER-2, EGFR, CK5/6, CK8, CK18).

Results

Classification of genomic profiles through cluster analysis revealed four subgroups, three of which displayed

SUBMITTER: Stefansson OA 

PROVIDER: S-EPMC2750106 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature