An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer.

ABSTRACT:

Introduction

Perhaps the major challenge in developing more effective therapeutic strategies for the treatment of breast cancer patients is confronting the heterogeneity of the disease, recognizing that breast cancer is not one disease but multiple disorders with distinct underlying mechanisms. Gene-expression profiling studies have been used to dissect this complexity, and our previous studies identified a series of intrinsic subtypes of breast cancer that define distinct populations of patients with respect to survival. Additional work has also used signatures of oncogenic pathway deregulation to dissect breast cancer heterogeneity as well as to suggest therapeutic opportunities linked to pathway activation.

Methods

We used genomic analyses to identify relations between br

SUBMITTER: Bild AH 

PROVIDER: S-EPMC2750116 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature