Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.

ABSTRACT:

Introduction

Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to the appearance of the therapy-resistant cancer cells that produce clinical relapse. Functional expression cloning in two independent laboratories has identified Finkel-Biskis-Reilly murine sarcoma virus-associated ubiquitously expressed gene (Fau) as a novel apoptosis regulator and candidate tumour suppressor. Fau modifies apoptosis-controller Bcl-G, which is also a key target for candidate oncoprotein maternal embryonic leucine zipper kinase (MELK).

Methods

We have used RNA interference to downregulate Fau and Bcl-G expression, b

SUBMITTER: Pickard MR 

PROVIDER: S-EPMC2750122 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature