Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.

ABSTRACT:

Introduction

Rho signaling regulates key cellular processes including proliferation, survival, and migration, and it has been implicated in the development of many types of cancer including breast cancer. P190B Rho GTPase activating protein (RhoGAP) functions as a major inhibitor of the Rho GTPases. P190B is required for mammary gland morphogenesis, and overexpression of p190B in the mammary gland induces hyperplastic lesions. Hence, we hypothesized that p190B may play a pivotal role in mammary tumorigenesis.

Methods

To investigate the effects of loss of p190B function on mammary tumor progression, p190B heterozygous mice were crossed with an MMTV-Neu breast cancer model. Effects of p190B deficiency on tumor latency, multiplicity, growth, preneoplastic progression and metast

SUBMITTER: Heckman-Stoddard BM 

PROVIDER: S-EPMC2750123 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature