Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin.

ABSTRACT:

Introduction

Critically ill patients requiring intensive care uniformly develop insulin resistance. This is most pronounced in patients with sepsis. Recently, several hormones secreted by adipose tissue have been identified to be involved in overall insulin sensitivity in metabolic syndrome-related conditions. However, little is known about these adipokines in critical illness.

Methods

We studied circulating levels of the adipokines adiponectin, retinol-binding protein 4 (RBP4), and leptin during critical illness, and the impact of intensive insulin therapy, a therapy shown to affect insulin sensitivity, in serum samples from prolonged critically ill patients with a respiratory critical illness (n = 318). For comparison, we studied healthy subjects (n = 22) and acutely stres

SUBMITTER: Langouche L 

PROVIDER: S-EPMC2750156 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature