Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.

ABSTRACT: There is some evidence that oxidative stress plays a role in lead-induced toxicity. Mechanisms for dealing with oxidative stress may be of particular relevance in the brain given the high rate of oxygen metabolism. Using a hospital-based case-control study, we investigated the role of oxidative stress in the potential carcinogenicity of lead through examination of effect modification of the association between occupational lead exposure and brain tumors by single nucleotide polymorphisms in genes with functions related to oxidative stress. The study included 362 patients with glioma (176 of which had glioblastoma multiforme), 134 patients with meningioma, and 494 controls. Lead exposure was estimated by expert review of detailed job history data for each participant. We evaluated effect mo

SUBMITTER: Bhatti P 

PROVIDER: S-EPMC2750838 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature