Intelligent medical diagnostics via molecular logic.

ABSTRACT: In this communication, we describe the integration of microarray sensor technology with logic capability for screening combinations of proteins and DNA in a biological sample. In this system, we have demonstrated the use of a single platform amenable to both protein detection and protein-DNA detection using molecular logic gates. The pattern of protein and DNA inputs results in fluorescence outputs according to a truth table for AND and INHIBIT gates, thereby demonstrating the feasibility of performing medical diagnostics using a logic gate design. One possible application of this technique would be direct screening of various medical conditions that are dependent on combinations of diagnostic markers.

SUBMITTER: Konry T 

PROVIDER: S-EPMC2750850 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature