A catalytic, Bronsted base strategy for intermolecular allylic C-H amination.

ABSTRACT: A Brønsted base activation mode for oxidative, Pd(II)/sulfoxide-catalyzed, intermolecular C-H allylic amination is reported. N,N-diisopropylethylamine was found to promote amination of unactivated terminal olefins, forming the corresponding linear allylic amine products with high levels of stereo-, regio-, and chemoselectivity. The predictable and high selectivity of this C-H oxidation method enables late-stage incorporation of nitrogen into advanced synthetic intermediates and natural products.

SUBMITTER: Reed SA 

PROVIDER: S-EPMC2751613 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature