Transcriptional profiling differences for articular cartilage and repair tissue in equine joint surface lesions.

ABSTRACT:

Background

Full-thickness articular cartilage lesions that reach to the subchondral bone yet are restricted to the chondral compartment usually fill with a fibrocartilage-like repair tissue which is structurally and biomechanically compromised relative to normal articular cartilage. The objective of this study was to evaluate transcriptional differences between chondrocytes of normal articular cartilage and repair tissue cells four months post-microfracture.

Methods

Bilateral one-cm2 full-thickness defects were made in the articular surface of both distal femurs of four adult horses followed by subchondral microfracture. Four months postoperatively, repair tissue from the lesion site and grossly normal articular cartilage from within the same femorotibial joint were collecte

SUBMITTER: Mienaltowski MJ 

PROVIDER: S-EPMC2751772 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature