Cripto-1 overexpression is involved in the tumorigenesis of nasopharyngeal carcinoma.

ABSTRACT:

Background

Human Cripto-1, a member of the EGF-CFC family, is indispensable for early embryonic development. Cripto-1 plays an important oncogenic role during tumorigenesis and is overexpressed in a wide range of epithelial carcinomas, yet little is known about Cripto-1 in nasopharyngeal carcinoma (NPC). The aim of this study was to analyze the roles of Cripto-1 in the progression and clinical characteristics in NPC clinical samples and cell lines.

Methods

The expression of Cripto-1 at mRNA level was detected by the reverse transcription-polymerase chain reaction (RT-PCR) and real time RT-PCR, and western blot was used to examine the protein expression. Cripto-1 expression and its clinical characteristics were investigated by performing immunohistochemical analysis on a tota

SUBMITTER: Wu Z 

PROVIDER: S-EPMC2751776 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature