Epitopia: a web-server for predicting B-cell epitopes.

ABSTRACT:

Background

Detecting candidate B-cell epitopes in a protein is a basic and fundamental step in many immunological applications. Due to the impracticality of experimental approaches to systematically scan the entire protein, a computational tool that predicts the most probable epitope regions is desirable.

Results

The Epitopia server is a web-based tool that aims to predict immunogenic regions in either a protein three-dimensional structure or a linear sequence. Epitopia implements a machine-learning algorithm that was trained to discern antigenic features within a given protein. The Epitopia algorithm has been compared to other available epitope prediction tools and was found to have higher predictive power. A special emphasis was put on the development of a user-friendly gr

SUBMITTER: Rubinstein ND 

PROVIDER: S-EPMC2751785 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature