Bioinformatics analysis of metastasis-related proteins in hepatocellular carcinoma.

ABSTRACT:

Aim

To analyze the metastasis-related proteins in hepatocellular carcinoma (HCC) and discover the biomarker candidates for diagnosis and therapeutic intervention of HCC metastasis with bioinformatics tools.

Methods

Metastasis-related proteins were determined by stable isotope labeling and MS analysis and analyzed with bioinformatics resources, including Phobius, Kyoto encyclopedia of genes and genomes (KEGG), online mendelian inheritance in man (OMIM) and human protein reference database (HPRD).

Results

All the metastasis-related proteins were linked to 83 pathways in KEGG, including MAPK and p53 signal pathways. Protein-protein interaction network showed that all the metastasis-related proteins were categorized into 19 function groups, including cell cycle, apoptosis

SUBMITTER: Song PM 

PROVIDER: S-EPMC2751890 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature