Protein interaction network related to Helicobacter pylori infection response.

ABSTRACT:

Aim

To understand the complex reaction of gastric inflammation induced by Helicobacter pylori (H pylori) in a systematic manner using a protein interaction network.

Methods

The expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated into proteins. A network of protein interactions was constructed by searching the primary interactions of selected proteins. The constructed network was mathematically analyzed and its biological function was examined. In addition, the nodes on the network were checked to determine if they had any further functional importance or relation to other proteins by extending them.

Results

The scale-free network showing the relationship between inflammation and ca

SUBMITTER: Kim KK 

PROVIDER: S-EPMC2751996 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature