The repertoire of heterotrimeric G proteins and RGS proteins in Ciona intestinalis.

ABSTRACT:

Background

Heterotrimeric G proteins and regulators of G protein signaling (RGS) proteins are key downstream interacting partners in the G protein coupled receptor (GPCR) signaling pathway. The highly versatile GPCR transmembrane signaling system is a consequence of the coupling of a diverse set of receptors to downstream partners that include multiple subforms of G proteins and regulatory proteins including RGS proteins, among others. While the GPCR repertoire of Ciona intestinalis, representing the basal chordate is known, the repertoire of the heterotrimeric G proteins and RGS proteins is unknown.

Methodology/principal findings

In the present study, we performed an in-silico genome-wide search of C. intestinalis for its complement of G proteins and RGS proteins. The ident

SUBMITTER: Prasobh R 

PROVIDER: S-EPMC2752167 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature