Ontology highlight
ABSTRACT:
SUBMITTER: Keshelava N
PROVIDER: S-EPMC2752378 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Pediatric blood & cancer 20090901 3
Vorinostat, a histone deacetylase inhibitor, was evaluated against the in vitro and in vivo childhood solid tumor and leukemia models in the Pediatric Preclinical Testing Program (PPTP). In vitro testing was performed by the DIMSCAN cytotoxicity assay. In vivo, vorinostat was administered intraperitoneally to mice bearing xenografts. Vorinostat demonstrated 2-log cell growth inhibitory activity in vitro, but generally at concentrations not sustainable in the clinic. No objective responses were o ...[more]