Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis.

ABSTRACT: We sought a genotype-phenotype association: between single-nucleotide polymorphisms (SNPs) in olfactory receptor (OR) genes from the two largest OR gene clusters and odor-triggered nonallergic vasomotor rhinitis (nVMR). In the initial pedigree screen, using transmission disequilibrium test (TDT) analysis, six SNPs showed "significant" p-values between 0.0449 and 0.0043. In a second case-control population, the previously identified six SNPs did not re-emerge, whereas four new SNPs showed p-values between 0.0490 and 0.0001. Combining both studies, none of the SNPs in the TDT analysis survived the Bonferroni correction. In the population study, one SNP showed an empirical p-value of 0.0066 by shuffling cases and controls with 10(5) replicates; however, the p-value for this SNP was 0.83 in th

SUBMITTER: Bernstein JA 

PROVIDER: S-EPMC2752410 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature