A cross-study gene set enrichment analysis identifies critical pathways in endometriosis.

ABSTRACT:

Background

Endometriosis is an enigmatic disease. Gene expression profiling of endometriosis has been used in several studies, but few studies went further to classify subtypes of endometriosis based on expression patterns and to identify possible pathways involved in endometriosis. Some of the observed pathways are more inconsistent between the studies, and these candidate pathways presumably only represent a fraction of the pathways involved in endometriosis.

Methods

We applied a standardised microarray preprocessing and gene set enrichment analysis to six independent studies, and demonstrated increased concordance between these gene datasets.

Results

We find 16 up-regulated and 19 down-regulated pathways common in ovarian endometriosis data sets, 22 up-regulated an

SUBMITTER: Zhao H 

PROVIDER: S-EPMC2752458 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature