Testing the hypothesis of tissue selectivity: the intersection-union test and a Bayesian approach.

ABSTRACT:

Motivation

Finding genes that are preferentially expressed in a particular tissue or condition is a problem that cannot be solved by standard statistical testing procedures. A relatively unknown procedure that can be used is the intersection-union test (IUT). However, two disadvantages of the IUT are that it is conservative and it conveys only the information of the least differing target tissue-other tissue pair.

Results

We propose a Bayesian procedure that quantifies how much evidence there is in the overall expression profile for selective over-expression. In a small simulation study, it is shown that the proposed method outperforms the IUT when it comes to finding selectively expressed genes. An application to publicly available data consisting of 22 tissues shows that t

SUBMITTER: Van Deun K 

PROVIDER: S-EPMC2752611 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature