Total synthesis of irciniastatin A (Psymberin).

ABSTRACT: The total synthesis of (+)-iriciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis.

SUBMITTER: Crimmins MT 

PROVIDER: S-EPMC2752752 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature