Large-fiber dysfunction in diabetic peripheral neuropathy is predicted by cardiovascular risk factors.

ABSTRACT:

Objective

Diabetic large-nerve fiber dysfunction, as measured by vibration perception threshold (VPT), predicts foot ulceration, amputation, and mortality. Thus, determination of modifiable risk factors is of great clinical importance.

Research design and methods

We assessed 1,407 patients with type 1 diabetes and a normal VPT participating in the EURODIAB Prospective Complications Study, at baseline mean +/- SD age of 32.7 +/- 10.2 years with diabetes duration of 14.7 +/- 9.3 years and follow-up of 7.3 +/- 0.6 years. VPT was measured using biothesiometry on the right big toe and medial malleolus. An abnormal result was defined as >2 SD from the predicted mean for the patient s age.

Results

An abnormal VPT was associated with an increased incidence of gangrene, amputa

SUBMITTER: Elliott J 

PROVIDER: S-EPMC2752908 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature