Insulin-based versus triple oral therapy for newly diagnosed type 2 diabetes: which is better?

ABSTRACT:

Objective

Early use of insulin after diagnosis of type 2 diabetes is met with resistance because of associated weight gain, hypoglycemia, and fear of decreased compliance and quality of life (QoL).

Research design and methods

In treatment-naive patients with newly diagnosed type 2 diabetes, insulin and metformin were initiated for a 3-month lead-in period, then patients were randomly assigned to insulin and metformin (insulin group) or metformin, pioglitazone, and glyburide (oral group) for 36 months. Hypoglycemic events, compliance, A1C, weight, QoL, and treatment satisfaction were assessed.

Results

Of 29 patients randomly assigned into each group, 83% (insulin group) and 72% (oral group) completed this 3-year study. At study completion, A1C was 6.1 +/- 0.6% (insulin

SUBMITTER: Lingvay I 

PROVIDER: S-EPMC2752924 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature