Endothelial markers may link kidney function to cardiovascular events in type 2 diabetes.

ABSTRACT:

Objective

The increased cardiovascular risk in diabetes has been linked to endothelial and renal dysfunction. The aim of this study was to investigate the role of stable fragments of the precursors of adrenomedullin, endothelin-1, vasopressin, and atrial natriuretic peptide in progression of cardiovascular disease in patients with diabetes.

Research design and methods

This was a prospective, observational study design with a composite end point (death or unexpected admission to hospital due to a cardiovascular event) on 781 patients with type 2 diabetes (54 events, median duration of observation 15 months). The four stable precursor peptides midregional adrenomedullin (MR-proADM), midregional proatrial natriuretic peptide (MR-proANP), COOH-terminal proendothelin-1 (CT-proET-

SUBMITTER: Maier C 

PROVIDER: S-EPMC2752942 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature