Insulin-like growth factor-1 promoter polymorphisms and colorectal cancer: a functional genomics approach.

ABSTRACT:

Rationale

Insulin-like growth factor-1 (IGF1) has been proposed to mediate the obesity-related carcinogenic effects of "Western lifestyle". While genetic factors explain at least half of inter-individual IGF1 variation, the IGF1 polymorphisms hypothesised to underlie the variation in cancer incidence rates remain ill-defined.

Methods

We used a comparative genomics approach to identify putative regulatory polymorphisms in the IGF1 promoter region within a rapidly westernising population, the Singapore Chinese. Association of IGF1 genotype with colorectal cancer risk was assessed among 298 colorectal cancer cases and 1142 controls nested within the Singapore Chinese Health Study.

Results

We identified a common (minor allele frequency = 0.36) single-nucleotide polymorphi

SUBMITTER: Wong HL 

PROVIDER: S-EPMC2752962 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature