Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.

ABSTRACT:

Objectives

Eicosanoids are lipid mediators that may play a role in atherosclerosis. We investigated the association of common genetic variation in prostaglandin H synthase 1 (PTGS1), prostaglandin H synthase 2 (PTGS2), thromboxane A2 synthase (TBXAS1), prostacyclin synthase (PTGIS), prostaglandin E synthase (PTGES), 5-lipoxygenase activating protein (ALOX5AP), 12-lipoxygenase (ALOX12) and 15-lipoxygenase (ALOX15) with the risks of myocardial infarction (MI) and ischemic stroke. A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC).

Methods

We conducted a case-control study in a large Health Maintenance Organization. Cases were men and wome

SUBMITTER: Lemaitre RN 

PROVIDER: S-EPMC2753183 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature