Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing.

ABSTRACT:

Background

Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity.

Objectives

We sought to examine the effectiveness of episodic use of an inhaled corticosteroid and a leukotriene receptor antagonist in preschoolers with intermittent wheezing.

Methods

In a randomized, double-blind, placebo-controlled 12-month trial, 238 children aged 12 to 59 months with moderate-to-severe intermittent wheezing received 7 days of either budesonide inhalation suspension (1 mg twice daily), montelukast (4 mg daily), or placebo in addition to albuterol with each identified respiratory tract illness (RTI). Proportion of episode-free days (EFDs) during the 12-month trial was the primary outcome.

Results

The 3 treatment groups did not differ

SUBMITTER: Bacharier LB 

PROVIDER: S-EPMC2753208 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature