Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma.

ABSTRACT:

Background & aims

Androgen effects on hepatocellular carcinoma (HCC) remain controversial and androgen ablation therapy to treat HCC also leads to inconsistent results. Here we examine androgen receptor (AR) roles in hepatocarcinogenesis using mice lacking AR in hepatocytes.

Methods

By using the Cre-Lox conditional knockout mice model injected with carcinogen, we examined the AR roles in hepatocarcinogenesis. We also tested the possible roles of AR in cellular oxidative stress and DNA damage sensing/repairing systems. By using AR degrading compound, ASC-J9, or AR-small interference RNA, we also examined the therapeutic potentials of targeting AR in HCC.

Results

We found AR expression was increased in human HCC compared with normal livers. We also found mice lacking he

SUBMITTER: Ma WL 

PROVIDER: S-EPMC2753209 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature