Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling.

ABSTRACT: The management of pain and morbidity due to the spreading and growth of cancer within bone remains to be a paramount problem in clinical care. Cancer cells actively transform bone, however, the molecular requirements and mechanisms of this process remain unclear. This study shows that functional modulation of the alphavbeta3 integrin receptor in prostate cancer cells is required for progression within bone and determines tumor-induced bone tissue transformation. Using histology and quantitative microCT analysis, we show that alphavbeta3 integrin is required not only for tumor growth within the bone but for tumor-induced bone gain, a response resembling bone lesions in prostate cancer patients. Expression of normal, fully functional alphavbeta3 enabled tumor growth in bone (incidence: 4/4),

SUBMITTER: McCabe NP 

PROVIDER: S-EPMC2753215 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature