Function of caspase-14 in trophoblast differentiation.

ABSTRACT:

Background

Within the human placenta, the cytotrophoblast consists of a proliferative pool of progenitor cells which differentiate to replenish the overlying continuous, multi-nucleated syncytiotrophoblast, which forms the barrier between the maternal and fetal tissues. Disruption to trophoblast differentiation and function may result in impaired fetal development and preeclampsia. Caspase-14 expression is limited to barrier forming tissues. It promotes keratinocyte differentiation by cleaving profilaggrin to stabilise keratin intermediate filaments, and indirectly providing hydration and UV protection. However its role in the trophoblast remains unexplored.

Methods

Using RNA Interference the reaction of control and differentiating trophoblastic BeWo cells to suppressed casp

SUBMITTER: White LJ 

PROVIDER: S-EPMC2753366 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature