Free radical polymers with tunable and selective bio- and chemical degradability.

ABSTRACT: A versatile synthetic strategy has been developed which enables the facile incorporation of cleavable functional groups, i.e., esters, thioesters, and disulfides, into the carbon-carbon backbone of vinyl-based polymers. Through the synthesis of novel cyclic monomers, RAFT-mediated radical ring-opening copolymerizations with traditional vinyl monomers such as methyl methacrylate, N,N-dimethylaminoethyl methacrylate, and 2-hydroxyethyl methacrylate lead to the introduction of controlled degradability into these widely used vinyl copolymer systems. An additional benefit of this strategy is the inherent versatility available through the incorporation of cyclic monomers containing diverse functional groups such as esters, thioesters, disulfides, and silyl ether units that allow degradation unde

SUBMITTER: Paulusse JM 

PROVIDER: S-EPMC2753401 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature