GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes.

ABSTRACT:

Background

The general population is constantly exposed to low levels of radiation through natural, occupational or medical irradiation. Even if the biological effects of low-level radiation have been intensely debated and investigated, the molecular mechanisms underlying the cellular response to low doses remain largely unknown.

Results

The present study investigated the role of GATA3 protein in the control of the cellular and molecular response of human keratinocytes exposed to a 1 cGy dose of X-rays. Chromatin immunoprecipitation showed GATA3 to be able to bind the promoter of 4 genes responding to a 1 cGy exposure. To go further into the role of GATA3 after ionizing radiation exposure, we studied the cellular and molecular consequences of radiation in GATA3 knock-down ce

SUBMITTER: Bonin F 

PROVIDER: S-EPMC2753551 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature