Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.

ABSTRACT:

Background

Burkholderia cenocepacia belongs to a group of closely related organisms called the B. cepacia complex (Bcc) which are important opportunistic human pathogens. B. cenocepacia utilizes a mechanism of cell-cell communication called quorum sensing to control gene expression including genes involved in virulence. The B. cenocepacia quorum sensing network includes the CepIR and CciIR regulatory systems.

Results

Global gene expression profiles during growth in stationary phase were generated using microarrays of B. cenocepacia cepR, cciR and cepRcciIR mutants. This is the first time CciR was shown to be a global regulator of quorum sensing gene expression. CepR was primarily responsible for positive regulation of gene expression while CciR generally exerted negative gen

SUBMITTER: O'Grady EP 

PROVIDER: S-EPMC2753556 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature